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Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, neuroradiological appearance of lesions, involvement of susceptibility gene loci, and response to therapy. These features are supported by experimental evidence, which demonstrates that fundamentally different processes, such as autoimmunity or virus infection, may induce MS-like inflammatory demyelinating plaques and suggest that MS may be a disease with heterogeneous pathogenetic mechanisms. At a given time point of the disease - as reflected in autopsy cases - the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient. This pathogenetic heterogeneity of plaques from different MS patients may have fundamental implications for the diagnosis and therapy of this disease. |
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multiple sclerosis
multiple sclerosis,etiology of
multiple sclerosis,pathogenesis
neuropathology
neuropathology,brain
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